Endocrine Abstracts

Background: Surgical resection of Nonfunctioning Pancreatic Neuroendocrine Tumor (NF-PanNET) is curative in most of the cases. Neoadjuvant treatments in patients with resectable NF-PanNET at high-risk of recurrence have never been investigated. Aim of this study was to test the safety and efficacy of neoadjuvant PRRT with 177Lu-DOTATATE followed by surgery in patients with resectable high-risk NF-PanNET.Methods: This was a multi-center single-...

Differentiated thyroid carcinoma (DTC) is the most frequent endocrine neoplasm. Follicular thyroid carcinoma (FTC) is the second histological variant in frequency after papillary thyroid carcinoma (PTC). Cerebellar metastases from DTC are extremely rare, corresponding about 1% of all cerebellar metastases, and being the majority metastases from PTC. To the best of our knowledge there have been no reported cerebellar metastases from CFT so far. We present here the first clinica...

Aim: To investigate the association between country incidence of type one diabetes (T1DM) and mortality from infectious disease as well as to antibiotic susceptibilityMaterials and methods: An ecological study correlating data from the WHO DiaMond Project for the incidence of T1DM, the WHO estimates of mortality (2004) from communicable diseases and the Alexander Project for bacterial susceptibility to antimicrobial agents.Results:...

The focus of the new guidelines of the European academy of andrology is on functional hypogonadism since the diagnosis and treatment is more controversial than for organic hypogonadism. It is important to consider functional hypogonadism, only following formal exclusion of organic hypogonadism. Diagnosis should be made on basis of both clinical symptoms as well as the biochemical confirmation of serum repeatedly low morning fasting testosterone. Most specific symptoms are sexu...

Background: The efficacy of PRRT is based upon NET over expression of somatostatin receptor (SSR) to deliver targeted isotope therapy. SSR expression (Krenning scale) compared to Predictive Quotient Index (PQI) (circulating NET transcript analysis mathematically integrated with grade) indicates the latter is more accurate for predicting PRRT efficacy. We evaluated whether PQI was specifically predictive or was prognostic for PRRT compared to other therapeutic strategi...

Background: Invasive nonfunctioning (NF) pituitary neuroendocrine tumors (PitNETs) are non-resectable neoplasms associated to frequent relapse and significant comorbidities. As current treatments often fail against NF-PitNETs, identifying actionable therapeutic targets is essential. We focused on the angiopoietin-2 (Angpt2)/Tie2 axis, usually active in endothelial cells (ECs).Methods: ANGPT2 plasma levels in NF-PitNET patients and healthy controls were m...

Introduction: Differentiated thyroid cancers (DTCs) carrying BRAF and TERT mutations are associated with high-risk clinicopathological features and poor prognosis. However, there are currently no studies comparing BRAF-TERT tumors to other double mutated DTCs.Aim: To verify whether BRAF-TERT mutated DTCs differ from other double mutated DTCs in terms of clinicopathological characteristics and outcome.Materials and Methods: 168 DTCs...

Introduction: There is no clear indication for radioiodine treatment (RAI) in patients affected by differentiated thyroid cancer (DTC) in Stage I and ATA intermediate risk, according to American Thyroid Association (ATA) guidelines.Purpose: Our aim is to evaluate whether integration of BRAF status and thyroglobulin TSH-stimulated at the time of RAI (A-HTg) could further improve accuracy of stratification, and therefore therapeutic management, in DTC pati...

Background: Since the preliminary epidemiological data concerning the coronavirus disease 2019 (COVID-19) has been availabe, clear sex disparity has been evident, with males, although not more frequently affected, often experiencing worse outcomes when compared to women. The short and long term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarified. The aim of the present study is to systematically review and meta-analyze all available data regardi...

Aim of the study: recurrence or persistence of hyperthyroidism occur in 15-25% of cases after radioiodine therapy (RAI) in Graves’ disease (GD). Our study aimed to establish prognostic factors affecting RAI outcome and to investigate if a tailored dosimetric approach based on the application of the “effective biological dose” (BED) offered a higher chance of success.Materials and methods: our cohort comprised 365 GD patients (280 women and...